2206788-99-8

2206788-99-8 structure

Name: CCR4 antagonist 2
Chemical Name: CCR4 antagonist 2
CAS Number: 2206788-99-8
Molecular Formula: C₂₆H₂₈Cl₂N₆O
Molecular Weight: 511.45
Catalog: Signaling Pathways GPCR/G Protein CCR
Create Date: 2019-09-07 12:30:18
Modify Date: 2024-01-09 15:39:47
CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues.CCR4 antagonist 2 (Compound 31) exhibits IC50 values of Ca2+flux and (chemotaxis) CTX are 40 nM and 70 nM, respectively[1].

Name	CCR4 antagonist 2

Description	CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues.CCR4 antagonist 2 (Compound 31) exhibits IC50 values of Ca2+flux and (chemotaxis) CTX are 40 nM and 70 nM, respectively[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CCR Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> CCR
Target	IC50: 40 nM (Ca2+flux); 70 nM (CTX) (CCR4 antagonist 2)[1]
References	[1]. Jackson JJ, et al. Discovery of a Potent and Selective CCR4 Antagonist That Inhibits Treg Trafficking into the Tumor Microenvironment. J Med Chem. 2019 Jul 11;62(13):6190-6213.

Molecular Formula	C₂₆H₂₈Cl₂N₆O
Molecular Weight	511.45