2244452-09-1
2244452-09-1 structure
- Name: BI-4924
- Chemical Name: BI-4924
- CAS Number: 2244452-09-1
- Molecular Formula: C21H20Cl2N2O6S
- Molecular Weight: 499.36
- Catalog: Research Areas Cancer
- Create Date: 2019-09-10 19:02:03
- Modify Date: 2025-08-24 21:03:23
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BI-4924 is a lipophilic, highly plasma protein bound selective phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=3 nM) with excellent microsomal, as well as hepatocytic stability. Intracellular trapping of BI-4924 disrupts serine biosynthesis with an IC50 of 2200 nM at 72 h[1].
| Name | BI-4924 |
|---|
| Description | BI-4924 is a lipophilic, highly plasma protein bound selective phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=3 nM) with excellent microsomal, as well as hepatocytic stability. Intracellular trapping of BI-4924 disrupts serine biosynthesis with an IC50 of 2200 nM at 72 h[1]. |
|---|---|
| Related Catalog | |
| Target |
PHGDH[1] |
| In Vitro | BI-4924 is a highly potent co-factor nicotinamide adenine dinucleotide (NADH/NAD+)-competitive PHGDH inhibitor. BI-4924 shows high selectivity against the majority of other dehydrogenase targets[1]. |
| References |
| Molecular Formula | C21H20Cl2N2O6S |
|---|---|
| Molecular Weight | 499.36 |