2095515-38-9
2095515-38-9 structure
- Name: RIP1-IN-22
- Chemical Name: RIP1 kinase inhibitor 1
- CAS Number: 2095515-38-9
- Molecular Formula: C24H20ClN5O3
- Molecular Weight: 461.90
- Catalog: Signaling Pathways Apoptosis RIP kinase
- Create Date: 2019-08-03 17:54:59
- Modify Date: 2024-01-13 23:00:18
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RIP1 kinase inhibitor 1 (compound 22) is a highly potent, orally available, and brain-penetrating RIP1 kinase inhibitor (pKi=9.04)[1].
| Name | RIP1 kinase inhibitor 1 |
|---|
| Description | RIP1 kinase inhibitor 1 (compound 22) is a highly potent, orally available, and brain-penetrating RIP1 kinase inhibitor (pKi=9.04)[1]. |
|---|---|
| Related Catalog | |
| Target |
pKi: 9.04 (RIP1 kinase)[1] |
| In Vitro | RIP1 kinase inhibitor 1 (compound 22) strongly suppresses necroptotic cell death and phosphorylation of MLKL(pMLKL) in human colorectal adenocarcinoma HT-29 cells (nectoptosis, IC50=2 nM; pMLKL, IC50=1.3 nM) as well as mouse L-cells NCTC 929 (nectoptosis, IC50=15 nM; pMLKL, IC50=2.7 nM)[1]. |
| References |
| Molecular Formula | C24H20ClN5O3 |
|---|---|
| Molecular Weight | 461.90 |