914291-61-5
914291-61-5 structure
- Name: PS372424
- Chemical Name: PS372424
- CAS Number: 914291-61-5
- Molecular Formula: C33H44N6O4
- Molecular Weight: 588.74
- Catalog: Signaling Pathways GPCR/G Protein CXCR
- Create Date: 2019-08-04 11:11:58
- Modify Date: 2025-08-25 15:58:37
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PS372424, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity, which inhibits the binding of CXCR3 ligand CXCL10 to CXCR3 receptor with IC50 of 42 nM[1][2][3].
| Name | PS372424 |
|---|
| Description | PS372424, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity, which inhibits the binding of CXCR3 ligand CXCL10 to CXCR3 receptor with IC50 of 42 nM[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
CXCR3 |
| In Vitro | PS372424 (10-200 nM; 30 min) causes a concentration-dependent phosphorylation of CCR5 on CXCR3+ T cells not in CXCR3- T cells[1]. Western Blot Analysis[1] Cell Line: CXCR3+ T cells and CXCR3- T cells Concentration: 10, 50, 100, or 200 nM Incubation Time: 30 minutes Result: Caused a concentration-dependent phosphorylation of CCR5 on CXCR3+ T cells. Did not result in phosphorylation of CCR5 on CXCR3- T cells. |
| References |
| Molecular Formula | C33H44N6O4 |
|---|---|
| Molecular Weight | 588.74 |