1469976-70-2

1469976-70-2 structure

Name: mPGES1-IN-17d
Chemical Name: mPGES1-IN-3
CAS Number: 1469976-70-2
Molecular Formula: C₂₄H₁₆ClF₅N₄O₃
Molecular Weight: 538.85
Catalog: Signaling Pathways Immunology/Inflammation PGE synthase
Create Date: 2019-08-04 09:18:58
Modify Date: 2025-08-27 09:05:11
mPGES1-IN-3 (Compound 17d) is a potent and selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor, which exhibits excellent mPGES-1 enzyme (IC50: 8 nM), cell (A549 IC50: 16.24 nM) and human whole blood potency (IC50: 249.9 nM)[1].

Name	mPGES1-IN-3

Description	mPGES1-IN-3 (Compound 17d) is a potent and selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor, which exhibits excellent mPGES-1 enzyme (IC50: 8 nM), cell (A549 IC50: 16.24 nM) and human whole blood potency (IC50: 249.9 nM)[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> PGE synthase
Target	IC50: 8 nM (mPGES-1)[1]
References	[1]. Muthukaman N, et al. Discovery of 2-((2-chloro-6-fluorophenyl)amino)-N-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-7,8-dihydro-1H-[1,4]dioxino[2',3':3,4]benzo[1,2-d]imidazole-5-carboxamide as potent, selective and efficacious microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5977-5984.

Molecular Formula	C₂₄H₁₆ClF₅N₄O₃
Molecular Weight	538.85