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Product Name: OTS186935
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2093400-18-9

2093400-18-9 structure

2093400-18-9 structure

Name: OTS186935
Chemical Name: OTS186935
CAS Number: 2093400-18-9
Molecular Formula: C₂₅H₂₆ClN₅O₂
Molecular Weight: 463.96
Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
Create Date: 2019-06-01 21:40:49
Modify Date: 2025-09-16 18:18:29
OTS186935 is a protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM[1].

Name	OTS186935

Description	OTS186935 is a protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Methyltransferase
Target	IC50: 6.49 nM (SUV39H2)[1]
In Vitro	OTS186935 inhibits A549 cell growth with IC50 of 0.67 μM[1].
In Vivo	OTS186935 reveales significant inhibition of tumor growth in mouse xenograft models using MDA-MB-231 breast cancer cells and A549 lung cancer cells without any detectable toxicity[1].
References	[1]. Vougiouklakis T, et al. Development of novel SUV39H2 inhibitors that exhibit growth suppressive effects in mouse xenograft models and regulate the phosphorylation of H2AX. Oncotarget. 2018 Aug 7;9(61):31820-31831.

Molecular Formula	C₂₅H₂₆ClN₅O₂
Molecular Weight	463.96

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