147660-55-7
147660-55-7 structure
- Name: BDA-410
- Chemical Name: BDA-410
- CAS Number: 147660-55-7
- Molecular Formula: C26H32N2O5S
- Molecular Weight: 484.61
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Proteasome
- Create Date: 2019-06-01 23:31:56
- Modify Date: 2024-01-11 15:55:04
-
BDA-410 is a cysteine protease inhibitor with ki values of 130 nM and 630 nM for calpain-1 and calpain-2, respevtively. BDA-410 inhibits recombinant falcipain-2B with an IC50 of 628 nM and exhibits anti-malarial effects[1].
| Name | BDA-410 |
|---|
| Description | BDA-410 is a cysteine protease inhibitor with ki values of 130 nM and 630 nM for calpain-1 and calpain-2, respevtively. BDA-410 inhibits recombinant falcipain-2B with an IC50 of 628 nM and exhibits anti-malarial effects[1]. |
|---|---|
| Related Catalog | |
| Target |
ki: 130 nM (Calpain-1), 630 nM (Calpain-2)[1] IC50: 628 nM (Recombinant falcipain-2B)[1] |
| In Vitro | BDA-410 inhibits malaria parasite growth in vitro with an IC50 value of 173 nM[1]. |
| In Vivo | BDA-410 (25 mg/kg; i.p. injection for three times per day; 4 days) rapidly clears parasitemia in vivo resulting in ~72% inhibition with no obvious detrimental effects due to inhibitor treatment in infected mice. All BDA-410 treated mice survive for longer[1]. Animal Model: C57BL/6 mice (4-6 weeks of age, 20-22g of weight)[1] Dosage: 25 mg/kg Administration: Given i.p. injection; three times per day for 4 days Result: Rapidly cleared parasitemia in vivo resulting in ~72% inhibition with no obvious detrimental effects due to inhibitor treatment in infected mice.BDA-410 treated mice survived until around day 23 compared with control group; and two of the eight BDA-410 treated mice survived until day 60. |
| References |
| Molecular Formula | C26H32N2O5S |
|---|---|
| Molecular Weight | 484.61 |