DC Chemicals Limited
China
Product Name: MM-589
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Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

2097887-20-0

2097887-20-0 structure

2097887-20-0 structure

Name: MM-589
Chemical Name: MM-589
CAS Number: 2097887-20-0
Molecular Formula: C₂₈H₄₄N₈O₅
Molecular Weight: 572.70
Catalog: Research Areas Cancer
Create Date: 2019-03-03 10:26:14
Modify Date: 2024-01-03 12:29:30
MM-589 is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM[1].

Name	MM-589

Description	MM-589 is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	IC50: 0.90 nM (WDR5), 12.7 nM (HMT)[1]
In Vitro	MM-589 (0.01-10 µM) potently and selectively inhibits cell growth in human leukemia cell lines harboring MLL translocations[1].
In Vivo	MM-589 has excellent microsomal stability in human, mouse, and rat microsomes[1].
References	[1]. Karatas H, et al. Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction. J Med Chem. 2017 Jun 22;60(12):4818-4839.

Molecular Formula	C₂₈H₄₄N₈O₅
Molecular Weight	572.70