727664-91-7

727664-91-7 structure

Name: MLS0315771
Chemical Name: MLS0315771
CAS Number: 727664-91-7
Molecular Formula: C₁₅H₁₂FNOS
Molecular Weight: 273.33
Catalog: Research Areas Metabolic Disease
Create Date: 2019-02-13 17:44:48
Modify Date: 2025-09-18 14:30:00
MLS0315771 is a potent and biologically active competitive phosphomannose isomerase (MPI) inhibitor, with an IC50 ~1 μM and a Ki of 1.4 μM.

Name	MLS0315771

Description	MLS0315771 is a potent and biologically active competitive phosphomannose isomerase (MPI) inhibitor, with an IC50 ~1 μM and a Ki of 1.4 μM.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
Target	IC50: ~1 μM (MPI)[1].
In Vitro	MLS0315771 increases mannose flux toward glycosylation. MLS0315771 toxicity at higher concentrations is an off-target effect. MLS0315771 is toxic to the zebrafish embryos above 2 μM. At 8-10 μM, ~50% embryos appeare sick within 20 min, and most of them die by 30-60 min[1].
References	[1]. Sharma V, et al. Phosphomannose isomerase inhibitors improve N-glycosylation in selected phosphomannomutase-deficient fibroblasts. J Biol Chem. 2011 Nov 11;286(45):39431-8.