1534358-79-6
1534358-79-6 structure
- Name: COH000
- Chemical Name: COH000
- CAS Number: 1534358-79-6
- Molecular Formula: C25H25NO5
- Molecular Weight: 419.47
- Catalog: Signaling Pathways Metabolic Enzyme/Protease E1/E2/E3 Enzyme
- Create Date: 2019-02-13 19:35:33
- Modify Date: 2024-01-10 19:39:16
-
COH000 is an inhibitor of Ubiquitin-like 1-activating enzyme (SUMO-activating enzyme), with an IC50 of 0.2 μM for SUMOylation in vitro[1].
| Name | COH000 |
|---|
| Description | COH000 is an inhibitor of Ubiquitin-like 1-activating enzyme (SUMO-activating enzyme), with an IC50 of 0.2 μM for SUMOylation in vitro[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.2 μM (SUMO-activating enzyme)[1]. |
| In Vitro | COH000 has over 500-fold selectivity for SUMOylation than ubiquitylation. COH000 inhibits SUMO adenylation without directly competing with ATP or SUMO1 binding. COH000 has an extremely slow off-rate and is consistent with it being covalently bound to the enzyme[1]. |
| References |
| Molecular Formula | C25H25NO5 |
|---|---|
| Molecular Weight | 419.47 |
| Storage condition | 2-8℃ |