2226507-04-4

2226507-04-4 structure

Name: BDP9066
Chemical Name: BDP9066
CAS Number: 2226507-04-4
Molecular Formula: C₂₀H₂₄N₆
Molecular Weight: 348.44
Catalog: Signaling Pathways GPCR/G Protein Ras
Create Date: 2019-03-02 19:52:03
Modify Date: 2024-01-11 12:15:28
BDP9066 is a potent and selective myotonic dystrophy-related Cdc42-binding kinases MRCK inhibitor with an IC50 of 64 nM for MRCKβ in SCC12 cells, Ki values of 0.0136 nM and 0.0233 nM for MRCKα/β in house determinations, respectively. BDP9066 has therapeutic effect on skin cancer by reducing substrate phosphorylation.

Name	BDP9066

Description	BDP9066 is a potent and selective myotonic dystrophy-related Cdc42-binding kinases MRCK inhibitor with an IC50 of 64 nM for MRCKβ in SCC12 cells, Ki values of 0.0136 nM and 0.0233 nM for MRCKα/β in house determinations, respectively. BDP9066 has therapeutic effect on skin cancer by reducing substrate phosphorylation.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
Target	IC50: 64 nM (MRCKβin SCC12 cells), Ki: 0.0136 nM/ 0.0233 nM (MRCKα/β)[1].
In Vitro	BDP9066 shows antiproliferative effects with greatest activity in hematologic cancer cells. BDP9066 inhibits MLC phosphorylation and blocks SCC12 squamous cell carcinoma motility and invasion[1].
In Vivo	BDP9066 topical application significantly decreases phosphorylated MRCKα S1003 staining and tumor volumes[1].
References	[1]. Unbekandt M, et al. Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer. Cancer Res. 2018 Apr 15;78(8):2096-2114.