1427058-33-0
1427058-33-0 structure
- Name: E 6130
- Chemical Name: E6130
- CAS Number: 1427058-33-0
- Molecular Formula: C28H37ClF3N3O3
- Molecular Weight: 556.06
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2018-09-08 17:42:26
- Modify Date: 2025-08-20 17:42:11
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E6130 is an orally available and highly selective CX3CR1 modulator, that may be effective for treatment of inflammatory bowel disease.
| Name | E6130 |
|---|
| Description | E6130 is an orally available and highly selective CX3CR1 modulator, that may be effective for treatment of inflammatory bowel disease. |
|---|---|
| Related Catalog | |
| Target |
CX3CR1 |
| In Vitro | E6130 is an orally available and highly selective CX3CR1 modulator, inhibits the fractalkine-induced chemotaxis of human peripheral blood natural killer cells (IC50, 4.9 nM), and down-regulates CX3CR1 on the cell surface of CD56+ NK cells with an EC50 value of 5.2 nM. E6130 also shows agonistic activity via CX3CR1 with respect to GTPγS binding (EC50 = 133 nM) and β-arrestin recruitment (EC50 = 2.4 μM) in CX3CR1-expressing CHO-K1 membrane but show no antagonistic activity[1]. |
| In Vivo | E6130 (10 or 30 mg/kg, p.o.) reduces several inflammatory bowel disease-related parameters in a murine CD4+ CD45RBhigh T-cell-transfer colitis model and a murine oxazolone-induced colitis model[1]. |
| References |
| Molecular Formula | C28H37ClF3N3O3 |
|---|---|
| Molecular Weight | 556.06 |