865363-93-5

865363-93-5 structure

Name: MK-8591
Chemical Name: 4'-ethynyl-2-fluoro-2'-deoxyadenosine
CAS Number: 865363-93-5
Molecular Formula: C₁₂H₁₂FN₅O₃
Molecular Weight: 293.2537832
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2018-11-30 18:29:58
Modify Date: 2025-08-25 18:08:18
MK-8591 is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively.

Name	4'-ethynyl-2-fluoro-2'-deoxyadenosine
Synonyms	MK-8591

Description	MK-8591 is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively.
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Signaling Pathways >> Anti-infection >> Reverse Transcriptase Research Areas >> Infection
Target	HIV-1 (WT):0.068 nM (EC50) HIV-1 (MDR):0.15 nM (EC50) HIV-1 (M184V):3.1 nM (EC50)
In Vitro	MK-8591 (4'Ed2FA) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively[1].
References	[1]. Ohrui H, et al. 2'-deoxy-4'-C-ethynyl-2-fluoroadenosine, a nucleoside reverse transcriptase inhibitor, is highly potent against all human immunodeficiency viruses type 1 and has low toxicity. Chem Rec. 2006;6(3):133-43.

Molecular Formula	C₁₂H₁₂FN₅O₃
Molecular Weight	293.2537832