439081-17-1

439081-17-1 structure

Name: (R)-Afatinib
Chemical Name: R-Afatinib
CAS Number: 439081-17-1
Molecular Formula: C₂₄H₂₅ClFN₅O₃
Molecular Weight: 485.9384032
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2018-12-05 21:30:16
Modify Date: 2024-01-14 10:27:09
(R)-Afatinib ((R)-BIBW 2992) is the Afatinib isomer. Afatinib (HY-10261) is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer[1].

Name	R-Afatinib

Description	(R)-Afatinib ((R)-BIBW 2992) is the Afatinib isomer. Afatinib (HY-10261) is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR
References	[1]. Li D, et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene. 2008 Aug 7;27(34):4702-11.

Molecular Formula	C₂₄H₂₅ClFN₅O₃
Molecular Weight	485.9384032