1818294-49-3

1818294-49-3 structure

Name: Azido-PEG8-TFP ester
Chemical Name: Azido-PEG8-TFP ester
CAS Number: 1818294-49-3
Molecular Formula: C₂₅H₃₇F₄N₃O₁₀
Molecular Weight: 615.569
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-17 13:14:41
Modify Date: 2025-08-27 14:40:52
Azido-PEG8-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Azido-PEG8-TFP ester
Synonyms	AZIDO-PEG8-TFP ESTER

Description	Azido-PEG8-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562