1353011-78-5

1353011-78-5 structure

Name: Bromoacetamido-PEG2-C2-NHS ester
Chemical Name: Bromoacetamido-PEG2- NHS ester
CAS Number: 1353011-78-5
Molecular Formula: C₁₃H₁₉BrN₂O₇
Molecular Weight: 395.203
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-07-13 19:36:26
Modify Date: 2025-08-23 13:40:03
Bromoacetamido-PEG2-C2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Bromoacetamido-PEG2- NHS ester
Synonyms	Acetamide, 2-bromo-N-[2-[2-[3-[(2,5-dioxo-1-pyrrolidinyl)oxy]-3-oxopropoxy]ethoxy]ethyl]- 2-Bromo-N-[2-(2-{3-[(2,5-dioxo-1-pyrrolidinyl)oxy]-3-oxopropoxy}ethoxy)ethyl]acetamide MFCD20926375

Description	Bromoacetamido-PEG2-C2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562