2028281-87-8

2028281-87-8 structure

Name: Azido-PEG4-(CH2)3OH
Chemical Name: Azido-PEG4-(CH2)3OH
CAS Number: 2028281-87-8
Molecular Formula: C₁₁H₂₃N₃O₅
Molecular Weight: 277.317
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-05 04:36:07
Modify Date: 2024-01-02 12:52:21
Azido-PEG4-(CH2)3OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Azido-PEG4-(CH2)3OH
Synonyms	AZIDO-PEG4-(CH2)3OH

Description	Azido-PEG4-(CH2)3OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.