143653-53-6
143653-53-6 structure
- Name: abciximab
- Chemical Name: abciximab
- CAS Number: 143653-53-6
- Molecular Formula:
- Molecular Weight:
- Catalog: Signaling Pathways Cytoskeleton Integrin
- Create Date: 2018-06-11 15:39:34
- Modify Date: 2024-01-04 21:23:15
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Abciximab (C7E3), a chimeric mouse/human monoclonal antibody, is a glycoprotein (GP) IIb/IIIa inhibitor. Abciximab inhibits platelet aggregation and leucocyte adhesion by binding to the glycoprotein IIb/IIIa, vitronectin and Mac-1 receptors[1].
| Name | abciximab |
|---|---|
| Synonyms | ABCIXIMAB |
| Description | Abciximab (C7E3), a chimeric mouse/human monoclonal antibody, is a glycoprotein (GP) IIb/IIIa inhibitor. Abciximab inhibits platelet aggregation and leucocyte adhesion by binding to the glycoprotein IIb/IIIa, vitronectin and Mac-1 receptors[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Abciximab (C7E3) inhibits platelet aggregation induced by physiologic and pathologic agonists by binding to the platelet αIIbβ3 integrin[2]. Abciximab appears to have similar affinity for the αIIbβ3 and αvβ3 integrins and redistributes between them[2]. |
| In Vivo | Abciximab (C7E3) (0.25 mg/kg/day; i.v.; 28 days) effectively prevents neointimal hyperplasia[2]. Animal Model: Male Wistar rats weighing 200-250 g, balloon angioplasty model[2] Dosage: 0.25 mg/kg/day Administration: Intravenous injection, 28 days Result: Time-dependently inhibited both neointimal hyperplasia and lumen occlusion after angioplasty in carotid arteries of rats. Significantly reduced PDGF-BB expression in vessel lumens and neointimal smooth muscle cells after angioplasty. Suppressed the elevation of plasma TxB2 concentration. |
| References |
| No Any Chemical & Physical Properties |