1383658-09-0
1383658-09-0 structure
- Name: m-PEG10-amine
- Chemical Name: m-PEG10-amine
- CAS Number: 1383658-09-0
- Molecular Formula: C21H45NO10
- Molecular Weight: 471.583
- Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
- Create Date: 2018-12-02 04:43:26
- Modify Date: 2024-01-10 17:17:34
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m-PEG10-amine is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG10-amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | m-PEG10-amine |
|---|---|
| Synonyms |
2,5,8,11,14,17,20,23,26,29-Decaoxahentriacontan-31-amine
MFCD27977522 |
| Description | m-PEG10-amine is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG10-amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs Non-cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
[1]. Jennifer Riggs-Sauthier, et al. Polymer-semaxanib moiety conjugates. US20140011855A1. |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 518.9±45.0 °C at 760 mmHg |
| Molecular Formula | C21H45NO10 |
| Molecular Weight | 471.583 |
| Flash Point | 254.4±22.4 °C |
| Exact Mass | 471.304352 |
| LogP | -3.88 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.456 |
| Storage condition | 2-8°C |