138168-48-6
138168-48-6 structure
- Name: Tyroserleutide (YSL)
- Chemical Name: Tyroserleutide
- CAS Number: 138168-48-6
- Molecular Formula: C18H27N3O6
- Molecular Weight: 381.423
- Catalog: Research Areas Cancer
- Create Date: 2019-01-02 09:17:05
- Modify Date: 2025-08-25 20:11:54
-
Tyroserleutide (YSL), isolated from the degradation products of porcine spleen[1], is a small molecular tripeptide which inhibits tumor growth both in vitro and in vivo[2].
| Name | Tyroserleutide |
|---|---|
| Synonyms |
L-Tyrosyl-L-seryl-L-leucine
L-Leucine, L-tyrosyl-L-seryl- |
| Description | Tyroserleutide (YSL), isolated from the degradation products of porcine spleen[1], is a small molecular tripeptide which inhibits tumor growth both in vitro and in vivo[2]. |
|---|---|
| Related Catalog | |
| Target |
Antitumor tripeptide[1][2] |
| In Vitro | Tyroserleutide (YSL) exhibits immuno-modulating effects, such as enhancing concanavalin (ConA) induced proliferation of mouse spleen lymphocytes, phagocytosis of mouse peritoneal macrophages, and the activity of natural killer (NK) cells[1]. Tyroserleutide (YSL), an immunologically therapeutic tripeptide, can promote hepatocarcinoma cell (H22) apoptosis through downregulating Bcl-2 and cyclin D1 expression[2]. Tyroserleutide is an ideal choice for inducing apoptosis of liver tumor cells[2]. Tyroserleutide inhibits tumor growth and does not cause severe toxicities in the major organs. Tyroserleutide can inhibit tumor cell migration[2]. |
| In Vivo | Tyroserleutide (10-80 μg/kg; injection (i.p.) one time every day until mice are dead) displays obvious anti-tumor activity. Tyroserleutide significantly prolongs the survival time of the murine H22 implanted mice[1]. Animal Model: Female Kun-Ming mice (18-22 g, 6 week old) with H22 tumor model[1] Dosage: 10, 20, 40, and 80 μg/kg Administration: Injection (i.p.) one time every day until mice were dead. Result: Survival times are 25.53±14.14, 25.82±14.29, 30.47±17.89, 35.06±20.90 days for 10, 20, 40, and 80 μg/kg, respectively. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 763.8±60.0 °C at 760 mmHg |
| Molecular Formula | C18H27N3O6 |
| Molecular Weight | 381.423 |
| Flash Point | 415.7±32.9 °C |
| Exact Mass | 381.189972 |
| LogP | 0.89 |
| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
| Index of Refraction | 1.577 |