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1263046-77-0

1263046-77-0 structure
1263046-77-0 structure
  • Name: Amino-PEG2-(CH2)3COOH
  • Chemical Name: Amino-PEG2-(CH2)3CO2H
  • CAS Number: 1263046-77-0
  • Molecular Formula: C8H17NO4
  • Molecular Weight: 191.225
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-06-05 09:31:30
  • Modify Date: 2025-08-21 18:24:49
  • Amino-PEG2-(CH2)3COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name Amino-PEG2-(CH2)3CO2H
Synonyms Butanoic acid, 4-[2-(2-aminoethoxy)ethoxy]-
MFCD22017705
4-[2-(2-Aminoethoxy)ethoxy]butanoic acid
Description Amino-PEG2-(CH2)3COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.1±0.1 g/cm3
Boiling Point 345.8±27.0 °C at 760 mmHg
Molecular Formula C8H17NO4
Molecular Weight 191.225
Flash Point 162.9±23.7 °C
Exact Mass 191.115753
LogP -0.99
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.468
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