1015171-69-3

1015171-69-3 structure

Name: Methyl salvionolate A
Chemical Name: (2R)-3-(3,4-Dihydroxyphenyl)-1-methoxy-1-oxo-2-propanyl (2E)-3-{2-[(E)-2-(3,4-dihydroxyphenyl)vinyl]-3,4-dihydroxyphenyl}acrylate
CAS Number: 1015171-69-3
Molecular Formula: C₂₇H₂₄O₁₀
Molecular Weight: 508.474
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2018-07-18 23:08:37
Modify Date: 2024-02-03 11:20:46
Methyl salvionolate A is a potent inhibitor of HIV-1. Methyl salvionolate A inhibits P24 antigen in HIV-1 infected MT-4 cell with an EC50 of 1.62 μg/ml. Methyl salvionolate A also inhibits HIV-1 reverse transcriptase, protease and integrase with IC50s of 50.58, 10.73 and 7.58 μg/ml, respectively[1].

Name	(2R)-3-(3,4-Dihydroxyphenyl)-1-methoxy-1-oxo-2-propanyl (2E)-3-{2-[(E)-2-(3,4-dihydroxyphenyl)vinyl]-3,4-dihydroxyphenyl}acrylate
Synonyms	(2R)-3-(3,4-Dihydroxyphenyl)-1-methoxy-1-oxo-2-propanyl (2E)-3-{2-[(E)-2-(3,4-dihydroxyphenyl)vinyl]-3,4-dihydroxyphenyl}acrylate Benzenepropanoic acid, α-[[(2E)-3-[2-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxy-, methyl ester, (αR)- Methyl salvionolate A

Description	Methyl salvionolate A is a potent inhibitor of HIV-1. Methyl salvionolate A inhibits P24 antigen in HIV-1 infected MT-4 cell with an EC50 of 1.62 μg/ml. Methyl salvionolate A also inhibits HIV-1 reverse transcriptase, protease and integrase with IC50s of 50.58, 10.73 and 7.58 μg/ml, respectively[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
References	[1]. Wang Q, et al. Salviachinensines A-F, Antiproliferative Phenolic Derivatives from the Chinese Medicinal Plant Salvia chinensis. J Nat Prod. 2018 Nov 26;81(11):2531-2538. [2]. Zhang ZF, et al. Three new derivatives of anti-HIV-1 polyphenols isolated from Salvia yunnanensis. J Asian Nat Prod Res. 2008 May-Jun;10(5-6):391-6.