1276197-22-8

1276197-22-8 structure

Name: Phthalic acid mono-2-ethylhexyl ester-d4
Chemical Name: 2-{[(2-Ethylhexyl)oxy]carbonyl}(2H4)benzoic acid
CAS Number: 1276197-22-8
Molecular Formula: C₁₆H₁₈D₄O₄
Molecular Weight: 282.37
Catalog: Research Areas Metabolic Disease
Create Date: 2018-06-23 08:27:00
Modify Date: 2024-01-29 09:43:11
Phthalic acid mono-2-ethylhexyl ester-d4 is a deuterium labeled Phthalic acid mono-2-ethylhexyl ester (HY-W018392). Phthalic acid mono-2-ethylhexyl ester (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP), which inhibits the 17, 20 lyase activity of CYP17[1][2].

Name	2-{[(2-Ethylhexyl)oxy]carbonyl}(2H4)benzoic acid
Synonyms	2-{[(2-Ethylhexyl)oxy]carbonyl}(2H4)benzoic acid 1,2-Benzene-d4-dicarboxylic acid, mono(2-ethylhexyl) ester

Description	Phthalic acid mono-2-ethylhexyl ester-d4 is a deuterium labeled Phthalic acid mono-2-ethylhexyl ester (HY-W018392). Phthalic acid mono-2-ethylhexyl ester (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP), which inhibits the 17, 20 lyase activity of CYP17[1][2].
Related Catalog	Research Areas >> Metabolic Disease
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-246. [2]. Bai J, et al. Mono-2-ethylhexyl phthalate induces the expression of genes involved in fatty acid synthesis in HepG2 cells. Environ Toxicol Pharmacol. 2019 Jul;69:104-111. [3]. Chauvigné F, et al. Mono-(2-ethylhexyl) phthalate directly alters the expression of Leydig cell genes and CYP17 lyase activity in cultured rat fetal testis. PLoS One. 2011;6(11):e27172.