1337878-62-2

1337878-62-2 structure

Name: ATI-2341 TFA
Chemical Name: N-Palmitoyl-L-methionylglycyl-L-tyrosyl-L-glutaminyl-L-lysyl-L-lysyl-L-leucyl-L-arginyl-L-seryl-L-methionyl-L-threonyl-L-α-aspartyl-L-lysyl-L-tyrosyl-L-arginyl-L-leucine
CAS Number: 1337878-62-2
Molecular Formula: C₁₀₄H₁₇₈N₂₆O₂₅S₂
Molecular Weight: 2256.82
Catalog: Signaling Pathways GPCR/G Protein CXCR
Create Date: 2018-06-26 14:24:40
Modify Date: 2024-01-15 09:11:40
ATI-2341 is a CXCR4 agonist, induces CXCR4-dependent calcium flux, with an EC50 of 194 nM in CCRF-CEM cells. ATI-2341 is also a potent and efficacious mobilizer of bone marrow hematopoietic cells[1].

Name	N-Palmitoyl-L-methionylglycyl-L-tyrosyl-L-glutaminyl-L-lysyl-L-lysyl-L-leucyl-L-arginyl-L-seryl-L-methionyl-L-threonyl-L-α-aspartyl-L-lysyl-L-tyrosyl-L-arginyl-L-leucine
Synonyms	N-Palmitoyl-L-methionylglycyl-L-tyrosyl-L-glutaminyl-L-lysyl-L-lysyl-L-leucyl-L-arginyl-L-seryl-L-methionyl-L-threonyl-L-α-aspartyl-L-lysyl-L-tyrosyl-L-arginyl-L-leucine L-Leucine, N-(1-oxohexadecyl)-L-methionylglycyl-L-tyrosyl-L-glutaminyl-L-lysyl-L-lysyl-L-leucyl-L-arginyl-L-seryl-L-methionyl-L-threonyl-L-α-aspartyl-L-lysyl-L-tyrosyl-L-arginyl-

Description	ATI-2341 is a CXCR4 agonist, induces CXCR4-dependent calcium flux, with an EC50 of 194 nM in CCRF-CEM cells. ATI-2341 is also a potent and efficacious mobilizer of bone marrow hematopoietic cells[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CXCR Research Areas >> Metabolic Disease Signaling Pathways >> Immunology/Inflammation >> CXCR
Target	CXCR4:194 nM (EC50, in CCRF-CEM cells)
In Vitro	ATI-2341 dose-dependently increases intracellular calcium in cells transfected with wild-type CXCR4 (EC50, 140 ± 36 nM)[1].
References	[1]. Tchernychev B, et al. Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells. Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22255-9.