1329643-44-8

1329643-44-8 structure

Name: (S)-(+)-Ibuprofen D3
Chemical Name: (2S)-2-(4-Isobutylphenyl)(3,3,3-2H3)propanoic acid
CAS Number: 1329643-44-8
Molecular Formula: C₁₃H₁₅D₃O₂
Molecular Weight: 209.299
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2018-06-07 15:05:00
Modify Date: 2025-08-25 11:45:10
(S)-(+)-Ibuprofen D3 ((S)-Ibuprofen D3) is a deuterium labeled (S)-(+)-Ibuprofen. (S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen that inhibits COX-1 and COX-2 activity with IC50s of 2.1 μM and 1.6 μM. (S)-(+)-Ibuprofen has analgesic, antiinflammatory and antipyretic effects[1][2].

Name	(2S)-2-(4-Isobutylphenyl)(3,3,3-2H3)propanoic acid
Synonyms	(2S)-2-(4-Isobutylphenyl)(3,3,3-2H3)propanoic acid Benzeneacetic acid, α-(methyl-d3)-4-(2-methylpropyl)-, (αS)-

Description	(S)-(+)-Ibuprofen D3 ((S)-Ibuprofen D3) is a deuterium labeled (S)-(+)-Ibuprofen. (S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen that inhibits COX-1 and COX-2 activity with IC50s of 2.1 μM and 1.6 μM. (S)-(+)-Ibuprofen has analgesic, antiinflammatory and antipyretic effects[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX-1:2.1 μM (IC50) COX-2:1.6 μM (IC50)
References	[1]. Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14. [2]. Xu HR, et al. The effect of CYP2C19 activity on pharmacokinetics of lansoprazole and its active metabolites in healthy subjects. Pharm Biol. 2010 Aug;48(8):947-52.