186392-43-8

186392-43-8 structure

Name: CP-316819
Chemical Name: 5-Chloro-N-{(2S,3R)-3-hydroxy-4-[methoxy(methyl)amino]-4-oxo-1-phenyl-2-butanyl}-1H-indole-2-carboxamide
CAS Number: 186392-43-8
Molecular Formula: C₂₁H₂₂ClN₃O₄
Molecular Weight: 415.870
Catalog: Research Areas Endocrinology
Create Date: 2018-07-12 20:35:23
Modify Date: 2024-03-25 23:02:33
CP 316819 is a potent glycogen phosphorylase (GPase) inhibitor with antihyperglycemic effect (IC50 values are 17 and 34 nM against human skeletal muscle glycogen phosphorylase (huSMGPa) and liver glycogen phosphorylase (huLGPa) respectively).CP 316819 causes glycogen accumulation under normoglycemic conditions but permits glycogen utilization when glucose concentrations are low.CP-316819 prevents neuronal cell death and maintains brain electrical currents[1][2].

Name	5-Chloro-N-{(2S,3R)-3-hydroxy-4-[methoxy(methyl)amino]-4-oxo-1-phenyl-2-butanyl}-1H-indole-2-carboxamide
Synonyms	5-Chloro-N-{(2S,3R)-3-hydroxy-4-[methoxy(methyl)amino]-4-oxo-1-phenyl-2-butanyl}-1H-indole-2-carboxamide 1H-Indole-2-carboxamide, 5-chloro-N-[(1S,2R)-2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-

Description	CP 316819 is a potent glycogen phosphorylase (GPase) inhibitor with antihyperglycemic effect (IC50 values are 17 and 34 nM against human skeletal muscle glycogen phosphorylase (huSMGPa) and liver glycogen phosphorylase (huLGPa) respectively).CP 316819 causes glycogen accumulation under normoglycemic conditions but permits glycogen utilization when glucose concentrations are low.CP-316819 prevents neuronal cell death and maintains brain electrical currents[1][2].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> Others >> Others
References	[1]. Baker DJ, Timmons JA, Greenhaff PL. Glycogen phosphorylase inhibition in type 2 diabetes therapy: a systematic evaluation of metabolic and functional effects in rat skeletal muscle. Diabetes. 2005 Aug;54(8):2453-9. [2]. Suh SW, Bergher JP, Anderson CM, Treadway JL, Fosgerau K, Swanson RA. Astrocyte glycogen sustains neuronal activity during hypoglycemia: studies with the glycogen phosphorylase inhibitor CP-316,819 ([R-R,S]-5-chloro-N-[2-hydroxy-3-(methoxymethylamino)-3