- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: IlexgeninA
- Price: ￥1478.0/20mg
- Purity: 98.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Ilexgenin A
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Stocking Period: 1 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: IlexgeninA
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
108524-94-3
108524-94-3 structure
- Name: IlexgeninA
- Chemical Name: Ilexgenin A
- CAS Number: 108524-94-3
- Molecular Formula: C30H46O6
- Molecular Weight: 502.683
- Catalog: Research Areas Cancer
- Create Date: 2018-10-16 13:23:16
- Modify Date: 2024-01-10 10:31:32
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Ilexgenin A is a pentacyclic triterpenoid, which extracted from Ilex hainanensis Merr. Ilexgenin A can be used for the research of inflammation and cancer[1].
| Name | Ilexgenin A |
|---|---|
| Synonyms |
Myriaboric acid
Urs-12-ene-24,28-dioic acid, 3,19-dihydroxy-, (3β)- (3β)-3,19-Dihydroxyurs-12-ene-24,28-dioic acid |
| Description | Ilexgenin A is a pentacyclic triterpenoid, which extracted from Ilex hainanensis Merr. Ilexgenin A can be used for the research of inflammation and cancer[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Ilexgenin A (0~100 μM; 24 hours; HT 29 and HCT 116 cells) effectively decreases cell viability in HT 29 and HCT 116 cells[1]. Ilexgenin A (12.5~50 μM; 24 hours; HT 29 cells) downregulates the expression of SREBP-1, inhibits the translocation of SREBP-1 to the nucleus and decreases the content of TG[1]. Ilexgenin A (12.5~50 μM; HT 29 and HCT 116 cells) induces cell cycle arrest at G1 phase in colon cancer cells[1]. Ilexgenin A (12.5~50 μM; 24 hours; HCT 116 cells) modulates lipid metabolism. Ilexgenin A (50 μM; 24 hours; HT 29 and HCT 116 cells) regulates SREBP-1 by inhibiting HIF1α[1]. Ilexgenin A inhibits fatty acids synthesis[1]. Cell Viability Assay[1] Cell Line: HT 29 and HCT 116 cells Concentration: 0~100 μM Incubation Time: 24 hours Result: Effectively decreased cell viability in HT 29 and HCT 116 cells. Western Blot Analysis[1] Cell Line: HT 29 cells Concentration: 12.5~50 μM Incubation Time: 24 hours Result: Downregulated the expression of SREBP-1. RT-PCR[1] Cell Line: HT 29 cells Concentration: 12.5~50 μM Incubation Time: 24 hours Result: Decreased the content of TG. Immunofluorescence[1] Cell Line: HT 29 cells Concentration: 12.5~50 μM Incubation Time: 24 hours Result: Inhibited the translocation of SREBP-1 to the nucleus. |
| In Vivo | Ilexgenin A (20 mg/kg) ameliorates the AOM/DSS induced carcinogenesis. Ilexgenin A can regulate lipid metabolism. Ilexgenin A decreases the expression of SREBP-1 and HIF 1α in AOM/DSS mice[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 653.3±55.0 °C at 760 mmHg |
| Molecular Formula | C30H46O6 |
| Molecular Weight | 502.683 |
| Flash Point | 362.9±28.0 °C |
| Exact Mass | 502.329437 |
| LogP | 5.77 |
| Vapour Pressure | 0.0±4.4 mmHg at 25°C |
| Index of Refraction | 1.587 |
| Storage condition | 2-8℃ |