836683-15-9

836683-15-9 structure

Name: Acumapimod
Chemical Name: Acumapimod
CAS Number: 836683-15-9
Molecular Formula: C₂₂H₁₉N₅O₂
Molecular Weight: 385.419
Catalog: Signaling Pathways MAPK/ERK Pathway p38 MAPK
Create Date: 2018-10-17 10:24:45
Modify Date: 2024-01-31 14:53:50
Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 μM for p38α.

Name	Acumapimod
Synonyms	Benzamide, 3-[5-amino-4-(3-cyanobenzoyl)-1H-pyrazol-1-yl]-N-cyclopropyl-4-methyl- 3-[5-Amino-4-(3-cyanobenzoyl)-1H-pyrazol-1-yl]-N-cyclopropyl-4-methylbenzamide acumapimod

Description	Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 μM for p38α.
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Inflammation/Immunology
Target	IC50: less than 1 μM (p38α)[1]
In Vitro	Acumapimod is an inhibitor of p38α with an IC50 value of less than 1 μM.
In Vivo	BCT197 is an oral low-molecular-weight p38 inhibitor currently in development for the treatment of several inflammatory conditions, including chronic obstructive pulmonary disease (COPD). Intermittent short-term dosing of BCT197 (75 mg on days 1 and 6) shows a marked improvement in lung function in COPD patients[2].
References	[1]. Norman P, et al. Investigational p38 inhibitors for the treatment of chronic obstructive pulmonary disease. Expert Opin Investig Drugs. 2015 Mar;24(3):383-92. [2]. De Buck S, et al. Population PK-PD Model for Tolerance Evaluation to the p38 MAP Kinase Inhibitor BCT197. CPT Pharmacometrics Syst Pharmacol. 2015 Dec;4(12):691-700.