347379-29-7

347379-29-7 structure

Name: LTV-1
Chemical Name: LTV-1
CAS Number: 347379-29-7
Molecular Formula: C₂₆H₂₀N₂O₅S
Molecular Weight: 472.512
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
Create Date: 2018-02-23 12:42:20
Modify Date: 2024-01-04 02:42:01
LTV-1 is a highly potent, cell-permeable and reversible inhibitor of lymphoid tyrosine phosphatase (LYP) (IC50 = 508 nM). IC50 value: 508 nMTarget: LYPin vitro: LTV-1 inhibits LYP in a dose-dependent manner at low- and sub-micromolar concentrations in T cells. LTV-1 enhances TCR signaling in intact cells. Exhibits competitive to mixed mode of inhibition (Ki = 384 nM). LTV-1 inhibits the mutant, disease associated LYP-Trp620 activity. LTV-1 blocks the action of the mutant LYP protein in human T cells.

Name	LTV-1
Synonyms	Benzoic acid, 3-[[4-[(E)-[tetrahydro-1-(2-methylphenyl)-4,6-dioxo-2-thioxo-5(2H)-pyrimidinylidene]methyl]phenoxy]methyl]- 3-[(4-{(E)-[1-(2-Methylphenyl)-4,6-dioxo-2-thioxotetrahydro-5(2H)-pyrimidinylidene]methyl}phenoxy)methyl]benzoic acid benzoic acid, 3-[[4-[(E)-[1,6-dihydro-2-mercapto-1-(2-methylphenyl)-4,6-dioxo-5(4H)-pyrimidinylidene]methyl]phenoxy]methyl]- 3-[(4-{(E)-[1-(2-methylphenyl)-4,6-dioxo-2-thioxotetrahydropyrimidin-5(2H)-ylidene]methyl}phenoxy)methyl]benzoic acid

Description	LTV-1 is a highly potent, cell-permeable and reversible inhibitor of lymphoid tyrosine phosphatase (LYP) (IC50 = 508 nM). IC50 value: 508 nMTarget: LYPin vitro: LTV-1 inhibits LYP in a dose-dependent manner at low- and sub-micromolar concentrations in T cells. LTV-1 enhances TCR signaling in intact cells. Exhibits competitive to mixed mode of inhibition (Ki = 384 nM). LTV-1 inhibits the mutant, disease associated LYP-Trp620 activity. LTV-1 blocks the action of the mutant LYP protein in human T cells.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase Research Areas >> Cancer
References	[1]. Vang T, et al. LYP inhibits T-cell activation when dissociated from CSK. Nat Chem Biol. 2012 Mar 18;8(5):437-446.