1142363-52-7

1142363-52-7 structure

Name: Edicotinib
Chemical Name: JNJ-40346527
CAS Number: 1142363-52-7
Molecular Formula: C₂₇H₃₅N₅O₂
Molecular Weight: 461.599
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-05-08 19:50:12
Modify Date: 2025-08-25 09:28:09
Edicotinib is a selective and orally available colony-stimulating factor-1 (CSF-1) receptor inhibitor, and has entered phase IIA clinical trial to study rheumatoid arthritis (RA) despite disease.

Name	JNJ-40346527
Synonyms	1H-Imidazole-2-carboxamide, 5-cyano-N-[2-(4,4-dimethyl-1-cyclohexen-1-yl)-6-(tetrahydro-2,2,6,6-tetramethyl-2H-pyran-4-yl)-3-pyridinyl]- 5-Cyano-N-[2-(4,4-dimethyl-1-cyclohexen-1-yl)-6-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-3-pyridinyl]-1H-imidazole-2-carboxamide

Description	Edicotinib is a selective and orally available colony-stimulating factor-1 (CSF-1) receptor inhibitor, and has entered phase IIA clinical trial to study rheumatoid arthritis (RA) despite disease.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	CSF-1 receptor[1]
References	[1]. Genovese MC, et al. Results from a Phase IIA Parallel Group Study of JNJ-40346527, an Oral CSF-1R Inhibitor, in Patients with Active Rheumatoid Arthritis despite Disease-modifying Antirheumatic Drug Therapy. J Rheumatol. 2015 Oct;42(10):1752-60.