885066-67-1

885066-67-1 structure

Name: prostaglandin D2(PGD2) inhibitor
Chemical Name: PGD2-IN-1
CAS Number: 885066-67-1
Molecular Formula: C₂₃H₂₃Cl₂N₃O₃
Molecular Weight: 460.353
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-05-06 12:30:11
Modify Date: 2024-01-10 07:01:52
PGD2-IN-1 is an antagonist of DP extracted from patent WO 2006044732 A2, example 15 (d); has an IC50 of 0.3 nM.

Name	PGD2-IN-1
Synonyms	Benzeneacetic acid, 3-[6-[[2-(2,4-dichlorophenyl)ethyl]amino]-2-methoxy-4-pyrimidinyl]-α,α-dimethyl- 2-[3-(6-{[2-(2,4-Dichlorophenyl)ethyl]amino}-2-methoxy-4-pyrimidinyl)phenyl]-2-methylpropanoic acid

Description	PGD2-IN-1 is an antagonist of DP extracted from patent WO 2006044732 A2, example 15 (d); has an IC50 of 0.3 nM.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	IC50: 0.3 nM[1]
In Vitro	Prostaglandin D2 (PGD2) is a major inflammatory mediator implicated in asthma and allergic rhinitis. It is largely produced as the major cyclooxygenase metabolite upon allergen-provoked degranulation from mast cells. Blockage of PGD2 using DP antagonistshave been shown to be effective at alleviating the symptoms of allergic rhinitis in multiple species and more specifically have been shown to inhibit the antigen-induced nasal congestion[1].
References	[1]. Patent: WO/2006/044732A2 [2]. Mu L, et al. Understanding DP receptor antagonism using a CoMSIA approach. Bioorg Med Chem Lett. 2011 Jan 1;21(1):66-75.