220355-63-5

220355-63-5 structure

Name: UKI-1
Chemical Name: UKI-1
CAS Number: 220355-63-5
Molecular Formula: C₃₂H₄₇N₅O₅S
Molecular Weight: 613.811
Catalog: Research Areas Infection
Create Date: 2018-03-02 21:47:37
Modify Date: 2024-01-10 17:51:02
UKI-1 is a novel synthetic inhibitor of the urokinase-type plasminogen activator system. It can also inhibits the invasive capacity of carcinoma cells. (Ki=0.41 μM)In vitro : A decrease of tumor cell invasion by up to 50% was achieved in both models with the SCCHN line FaDu and the cervical carcinoma line HeLa after treatment with UK1.

Name	UKI-1
Synonyms	1-Piperazinecarboxylic acid, 4-[(2S)-3-[3-(aminoiminomethyl)phenyl]-1-oxo-2-[[[2,4,6-tris(1-methylethyl)phenyl]sulfonyl]amino]propyl]-, ethyl ester Ethyl 4-{3-carbamimidoyl-N-[(2,4,6-triisopropylphenyl)sulfonyl]-L-phenylalanyl}-1-piperazinecarboxylate ethyl 4-(3-carbamimidoyl-N-{[2,4,6-tri(propan-2-yl)phenyl]sulfonyl}-L-phenylalanyl)piperazine-1-carboxylate

Description	UKI-1 is a novel synthetic inhibitor of the urokinase-type plasminogen activator system. It can also inhibits the invasive capacity of carcinoma cells. (Ki=0.41 μM)In vitro : A decrease of tumor cell invasion by up to 50% was achieved in both models with the SCCHN line FaDu and the cervical carcinoma line HeLa after treatment with UK1.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Infection
References	[1]. Ertongur S et al. Inhibition of the invasion capacity of carcinoma cells by WX-UK1, a novel synthetic inhibitor of the urokinase-type plasminogen activator system. Int J Cancer. 2004 Jul 20;110(6):815-24. [2]. Ewa Zeslawska et al. Crystals of the urokinase type plasminogen activator variant βc-uPA in complex with small molecule inhibitors open the way towards structure-based drug design. J Mol Biol. 2000 Aug 11;301(2):465-75.