1820565-69-2

1820565-69-2 structure

Name: PIM-447 dihydrochloride
Chemical Name: N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]-3-pyridinyl}-6-(2,6-difluorophenyl)-5-fluoro-2-pyridinecarboxamide dihydrochloride
CAS Number: 1820565-69-2
Molecular Formula: C₂₄H₂₅Cl₂F₃N₄O
Molecular Weight: 513.383
Catalog: Signaling Pathways JAK/STAT Signaling Pim
Create Date: 2018-04-02 09:34:34
Modify Date: 2024-04-05 19:33:07
PIM447 is a pan-PIM kinase ihibitor with Kis of 6, 18, 9 nM for PIM1, PIM2 and PIM3, respectively.

Name	N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]-3-pyridinyl}-6-(2,6-difluorophenyl)-5-fluoro-2-pyridinecarboxamide dihydrochloride
Synonyms	2-Pyridinecarboxamide, N-[4-[(1R,3S,5S)-3-amino-5-methylcyclohexyl]-3-pyridinyl]-6-(2,6-difluorophenyl)-5-fluoro-, hydrochloride (1:2) N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]-3-pyridinyl}-6-(2,6-difluorophenyl)-5-fluoro-2-pyridinecarboxamide dihydrochloride PIM-447 dihydrochloride PIM-447 (dihydrochloride)

Description	PIM447 is a pan-PIM kinase ihibitor with Kis of 6, 18, 9 nM for PIM1, PIM2 and PIM3, respectively.
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> Pim Research Areas >> Cancer
References	[1]. Paíno T et al. The novel pan-PIM kinase inhibitor, PIM447, displays dual anti-myeloma and bone protective effects, and potently synergizes with current standards of care. Clin Cancer Res. 2016 Jul 20. [2]. Burger MT et al. Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies. J Med Chem. 2015 Nov 12;58(21):8373-86. [3]. Peters TL et al. Control of translational activation by PIM kinase in activated B-cell diffuse large B-cell lymphoma confers sensitivity to inhibition by PIM447.Oncotarget. 2016 Aug 20