1380087-86-4
1380087-86-4 structure
- Name: CPI-268456
- Chemical Name: CPI-268456
- CAS Number: 1380087-86-4
- Molecular Formula: C20H15Cl2N3O2
- Molecular Weight: 400.258
- Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
- Create Date: 2018-05-16 00:49:52
- Modify Date: 2025-09-04 17:42:12
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BRD4-IN-3 (compound 141) is a potent BRD4 inhibitor with an IC50 of <0.5 µM. BRD4-IN-3 shows cytoxicity for MYC-Raji with an IC50 value of >1 µM[1].
| Name | CPI-268456 |
|---|---|
| Synonyms |
4H-Isoxazolo[5,4-d][2]benzazepine-4-acetamide, 8-chloro-6-(4-chlorophenyl)-1-methyl-, (4R)-
2-[(4R)-8-Chloro-6-(4-chlorophenyl)-1-methyl-4H-[1,2]oxazolo[5,4-d][2]benzazepin-4-yl]acetamide MFCD28987428 |
| Description | BRD4-IN-3 (compound 141) is a potent BRD4 inhibitor with an IC50 of <0.5 µM. BRD4-IN-3 shows cytoxicity for MYC-Raji with an IC50 value of >1 µM[1]. |
|---|---|
| Related Catalog | |
| Target |
BRD4:<0.5 μM (IC50) |
| References |
[1]. Brian K. Albrecht, et al. Bromodomain inhibitors and uses thereof. WO2012075383A2. |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 649.8±55.0 °C at 760 mmHg |
| Molecular Formula | C20H15Cl2N3O2 |
| Molecular Weight | 400.258 |
| Flash Point | 346.8±31.5 °C |
| Exact Mass | 399.054138 |
| LogP | 3.42 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.702 |