285986-31-4
285986-31-4 structure
- Name: STAT5-IN-1
- Chemical Name: N'-[(E)-(4-Oxo-4H-chromen-3-yl)methylene]nicotinohydrazide
- CAS Number: 285986-31-4
- Molecular Formula: C16H11N3O3
- Molecular Weight: 293.277
- Catalog: Signaling Pathways JAK/STAT Signaling STAT
- Create Date: 2018-04-14 16:59:22
- Modify Date: 2024-01-06 18:01:14
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STAT5-IN-1 is a STAT5 inhibitor with an IC50 of 47 μM for STAT5β isoform.
| Name | N'-[(E)-(4-Oxo-4H-chromen-3-yl)methylene]nicotinohydrazide |
|---|---|
| Synonyms |
N'-[(E)-(4-Oxo-4H-chromen-3-yl)methylene]nicotinohydrazide
N'3-[(4-oxo-4H-chromen-3-yl)methylidene]pyridine-3-carbohydrazide 3-Pyridinecarboxylic acid, 2-[(1E)-(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazide Stat5 Inhibitor STAT5-IN-1 |
| Description | STAT5-IN-1 is a STAT5 inhibitor with an IC50 of 47 μM for STAT5β isoform. |
|---|---|
| Related Catalog | |
| Target |
STAT5β:47 μM (IC50) |
| In Vitro | The signal transducer and activator of transcription 5 (STAT5) is a member of the STAT family of proteins, implicated in cell growth and differentiation. STAT5-IN-1 inhibits STAT5 by binding to the SH2 domain. The functions of the SH2 domains of STAT3, STAT1, and of the tyrosine kinase Lck are inhibited to a lesser extent (IC50>500 µM). STAT5-IN-1 block STAT5/STAT5 DNA binding in K562 nuclear extracts. Substitution of the hydrogen at C6 of the chromone ring by an ethyl group does not affect activity of STAT5-IN-1 against STAT5β, but leads to complete loss of selectivity against other STAT family members[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C16H11N3O3 |
| Molecular Weight | 293.277 |
| Exact Mass | 293.080048 |
| LogP | 1.76 |
| Index of Refraction | 1.657 |
| Storage condition | 2-8℃ |