1910124-24-1
1910124-24-1 structure
- Name: GSK6853
- Chemical Name: N-{1,3-Dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl}-2-methoxybenzamide
- CAS Number: 1910124-24-1
- Molecular Formula: C22H27N5O3
- Molecular Weight: 409.482
- Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
- Create Date: 2018-06-29 19:28:17
- Modify Date: 2025-08-25 10:31:01
-
GSK6853 is a potent and selective inhibitor of the BRPF1 bromodomain. shows excellent BRPF1 potency (pKd 9.5) andgreater than 1600-fold selectivity over all other bromodomainstested.target: BRPF1.[1]In vivo: The ip route of administration would be suitable for dosing GSK6853 in potential PK/PD models. [1]
| Name | N-{1,3-Dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl}-2-methoxybenzamide |
|---|---|
| Synonyms |
N-{1,3-Dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl}-2-methoxybenzamid
N-{1,3-Dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl}-2-methoxybenzamide Benzamide, N-[2,3-dihydro-1,3-dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-1H-benzimidazol-5-yl]-2-methoxy- N-{1,3-Diméthyl-6-[(2R)-2-méthyl-1-pipérazinyl]-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl}-2-méthoxybenzamide GSK6853 |
| Description | GSK6853 is a potent and selective inhibitor of the BRPF1 bromodomain. shows excellent BRPF1 potency (pKd 9.5) andgreater than 1600-fold selectivity over all other bromodomainstested.target: BRPF1.[1]In vivo: The ip route of administration would be suitable for dosing GSK6853 in potential PK/PD models. [1] |
|---|---|
| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 545.9±50.0 °C at 760 mmHg |
| Molecular Formula | C22H27N5O3 |
| Molecular Weight | 409.482 |
| Flash Point | 284.0±30.1 °C |
| Exact Mass | 409.211395 |
| LogP | 0.98 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.621 |
| Storage condition | -20℃ |