1446090-79-4
1446090-79-4 structure
- Name: Lifirafenib
- Chemical Name: 5-(((1R,1aS,6bR)-1-(6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-1a,6b-dihydro-1H-cyclopropa[b]benzofuran-5-yl)oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one
- CAS Number: 1446090-79-4
- Molecular Formula: C25H17F3N4O3
- Molecular Weight: 478.42300
- Create Date: 2018-06-21 07:33:42
- Modify Date: 2025-09-18 14:02:27
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Lifirafenib (BGB-283) potently inhibits RAF family kinases and EGFR activities in biochemical assays with IC50 values of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant.
| Name | 5-(((1R,1aS,6bR)-1-(6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-1a,6b-dihydro-1H-cyclopropa[b]benzofuran-5-yl)oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one |
|---|---|
| Synonyms | Lifirafenib |
| Molecular Formula | C25H17F3N4O3 |
|---|---|
| Molecular Weight | 478.42300 |
| Exact Mass | 478.12500 |
| PSA | 89.13000 |
| LogP | 5.43370 |
| Storage condition | -20℃ |