19942-02-0

19942-02-0 structure

Name: Gymnestrogenin
Chemical Name: (3β,16β,21β)-olean-12-ene-3,16,21,23,28-pentol
CAS Number: 19942-02-0
Molecular Formula: C₃₀H₅₀O₅
Molecular Weight: 490.71500
Catalog: Signaling Pathways Metabolic Enzyme/Protease LXR
Create Date: 2018-03-09 08:00:00
Modify Date: 2024-01-09 08:32:22
Gymnestrogenin is a pentahydroxytriterpene from the leaves of Gymnema sylvestre R.Br[1]. Gymnestrogenin is a LXR antagonist with IC50s of 2.5 and 1.4 μM for LXRα and LXRβ transactivation, respectively. Gymnestrogenin reduces the transcriptional activity of LXR even on its own promoter, thus reducing the mRNA expression[2].

Name	(3β,16β,21β)-olean-12-ene-3,16,21,23,28-pentol
Synonyms	Gymnestrogenin (3S,4aS,5S,6aS,6bR,8aR,9R,10S,12aR,12bR,14bS)-4a,9-Bis-hydroxymethyl-2,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydro-picene-3,5,10-triol gymnestrogenin 3β,16β,21β,23,28-pentahydroxyolean-12-ene

Description	Gymnestrogenin is a pentahydroxytriterpene from the leaves of Gymnema sylvestre R.Br[1]. Gymnestrogenin is a LXR antagonist with IC50s of 2.5 and 1.4 μM for LXRα and LXRβ transactivation, respectively. Gymnestrogenin reduces the transcriptional activity of LXR even on its own promoter, thus reducing the mRNA expression[2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> LXR Research Areas >> Metabolic Disease
Target	IC50: 2.5 μM (LXRα) and 1.4 μM (LXRβ)[2]
In Vitro	Gymnestrogenin, reducing the expression of SREBP1c and ABCA1 in vitro, is able to decrease lipid accumulation in HepG2 cells[2].
References	[1]. Stöcklin W, et al. [Gymnestrogenin, a new pentahydroxytriterpene from the leaves of Gymnema sylvestre R.Br]. Helv Chim Acta. 1968;51(6):1235-42. [2]. Renga B, et al. Molecular decodification of gymnemic acids from Gymnema sylvestre. Discovery of a new class of liver X receptor antagonists. Steroids. 2015 Apr;96:121-31.