Dayang Chem (Hangzhou) Co., Ltd.
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Product Name: HYPOGLYCINB
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502-37-4

502-37-4 structure

Name: HYPOGLYCINB
Chemical Name: L-γ-Glutamyl-3-[(1R)-2-methylenecyclopropyl]alanine
CAS Number: 502-37-4
Molecular Formula: C₁₂H₁₈N₂O₅
Molecular Weight: 270.28200
Create Date: 2016-06-28 05:07:45
Modify Date: 2024-01-12 16:21:07

Name	L-γ-Glutamyl-3-[(1R)-2-methylenecyclopropyl]alanine
Synonyms	Hypoglyin-B (S)-2-L-alanylamino-butyric acid (S)-2-L-Alanylamino-buttersaeure L-2-(L-2-Amino-propionylamino)-buttersaeure N-L-Alanyl-L-2-amino-buttersaeure

Density	1.33g/cm3
Boiling Point	592.8ºC at 760mmHg
Molecular Formula	C₁₂H₁₈N₂O₅
Molecular Weight	270.28200
Flash Point	312.3ºC
Exact Mass	270.12200
PSA	133.21000
LogP	1.25470
Index of Refraction	1.562

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AY6330000

CHEMICAL NAME :: Alanine, N-L-gamma-glutamyl-3-(methylenecyclopropyl)-

CAS REGISTRY NUMBER :: 502-37-4

BEILSTEIN REFERENCE NO. :: 3162184

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C12-H18-N2-O5

MOLECULAR WEIGHT :: 270.32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 121,272,1957

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 121,272,1957

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Endocrine - hypoglycemia

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 121,272,1957 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intrauterine

DOSE :: 500 ug/kg

SEX/DURATION :: female 14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 4,246,1971

406-09-7

502-37-4

Literature: Joehl; Stoll Helvetica Chimica Acta, 1959 , vol. 42, p. 716,717

45214-61-7

502-37-4

Literature: Joehl; Stoll Helvetica Chimica Acta, 1959 , vol. 42, p. 716,717

156-56-9

502-37-4

Literature: Joehl; Stoll Helvetica Chimica Acta, 1959 , vol. 42, p. 716,717

80514-73-4

502-37-4

Literature: Hassall; John Tetrahedron Letters, 1959 , # 3 p. 7

Precursor 3
45214-61-7 156-56-9 80514-73-4
DownStream 0

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