103963-39-9
103963-39-9 structure
- Name: (22S,24E)-3α,22-Bis(acetyloxy)-5α-lanosta-7,9(11),24-trien-26-oic acid
- Chemical Name: ganoderic acid R
- CAS Number: 103963-39-9
- Molecular Formula: C34H50O6
- Molecular Weight: 554.76
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2018-02-25 14:43:10
- Modify Date: 2024-01-05 12:58:02
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Ganoderic acid R is a potent anticancer agent. Ganoderic acid R inhibits the growth by inducing apoptosis on tumor cell line. Ganoderic acid R possesses significant cytotoxicity on a multidrug resistance (MDR) tumor cell line (KB-A-1/Dox) and a sensitive tumor cell line (KB-A-1)[1].
| Name | ganoderic acid R |
|---|---|
| Synonyms | (E)-(5S,6S)-5-Acetoxy-6-((3R,5R,10S,13R,14R,17R)-3-acetoxy-4,4,10,13,14-pentamethyl-2,3,4,5,6,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methyl-hept-2-enoic acid |
| Description | Ganoderic acid R is a potent anticancer agent. Ganoderic acid R inhibits the growth by inducing apoptosis on tumor cell line. Ganoderic acid R possesses significant cytotoxicity on a multidrug resistance (MDR) tumor cell line (KB-A-1/Dox) and a sensitive tumor cell line (KB-A-1)[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Ganoderic acid R (0-50 µg/mL, 48 h) 在浓度超过 20 µg/mL时通过诱导肿瘤细胞系凋亡来抑制生长[1]。 Apoptosis Analysis[1] Cell Line: KB-A-1/Dox cells Concentration: 0, 25, 50 μg/mL Incubation Time: 48 h Result: Induced the cellular apoptosis, the number of apoptotic cells was increased from 35% to 90% during 48 h. |
| References |
| Molecular Formula | C34H50O6 |
|---|---|
| Molecular Weight | 554.76 |
| Exact Mass | 554.36100 |
| PSA | 89.90000 |
| LogP | 7.43220 |