23665-96-5

23665-96-5 structure

Name: Neogrifolin
Chemical Name: Neogrifolin
CAS Number: 23665-96-5
Molecular Formula: C₂₂H₃₂O₂
Molecular Weight: 328.49
Catalog: Signaling Pathways GPCR/G Protein Ras
Create Date: 2018-06-14 16:03:58
Modify Date: 2025-08-25 20:33:09
Neogrifolin is an inhibitor of KRAS. Neogrifolin suppress KRAS expression in human colon cancer cells. Neogrifolin has anti-cell viability activity against HeLa, SW480 and HT29 cells wih IC50s of 24.3, 34.6, and 30.1 μM, respectively[1].

Name	Neogrifolin
Synonyms	neogrifolin 5-Methyl-4-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienyl)-benzene-1,3-diol

Description	Neogrifolin is an inhibitor of KRAS. Neogrifolin suppress KRAS expression in human colon cancer cells. Neogrifolin has anti-cell viability activity against HeLa, SW480 and HT29 cells wih IC50s of 24.3, 34.6, and 30.1 μM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Ras
References	[1]. Yaqoob A, et al. Grifolin, neogrifolin and confluentin from the terricolous polypore Albatrellus flettii suppress KRAS expression in human colon cancer cells. PLoS One. 2020 May 5;15(5):e0231948.