14417-88-0
14417-88-0 structure
- Name: Melinamide
- Chemical Name: Melinamide
- CAS Number: 14417-88-0
- Molecular Formula: C26H41NO
- Molecular Weight: 383.61000
- Catalog: Research Areas Metabolic Disease
- Create Date: 2018-02-27 11:17:23
- Modify Date: 2025-08-27 12:31:15
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Melinamide, an amide derivative of an unsaturated long-chain fatty acid, is an inhibitor of cholesterol absorption with an IC50 of 20.9 μM.
| Name | Melinamide |
|---|---|
| Synonyms |
linoleyl(methylbenzyl)amide
Artes oil melinamide (9Z,12Z)-Octadeca-9,12-dienoic acid (1-phenyl-ethyl)-amide N-α-methylbenzyl linoleamide N-(α-methylbenzyl)-9,12-(9Z,12Z)-octadecadienamide artes |
| Description | Melinamide, an amide derivative of an unsaturated long-chain fatty acid, is an inhibitor of cholesterol absorption with an IC50 of 20.9 μM. |
|---|---|
| Related Catalog | |
| Target |
IC50: 20.9 μM (cholesterol)[1] |
| In Vitro | DL-Melinamide inhibits acyl CoA:cholesterol acyltransferase activity (ACAT) in the mucosal microsomes, with 50% inhibition occurring at approximately 0.5 μM. Kinetic studies indicate that DL-Melinamide is an uncompetitive inhibitor of acyl CoA:cholesterol acyltransferase. D-Melinamide is found to be a more effective inhibitor than L-Melinamide[2]. |
| In Vivo | Melinamide is a new hypocholesterolaemic drug. Melinamide causes a substantial decrease of the enhanced intestinal ACAT activity in diabetic rats, but does not affect intestinal cholesterol esterase activity. Furthermore, marked improvement of hypercholesterolaemia in cholesterol-fed diabetic rats occurrs concomitantly with the drug treatment[3]. |
| Animal Admin | Rats: 10 diabetic rats are divided into two groups: a cholesterol-fed diabetic group and a melinamide-treated cholesterol-fed diabetic group. Five control rats are injected with citrate buffer only. The rats are fed each diet for 3 weeks after injection. The chol-fed DM group receives a diet (20 g/day) containing 1% cholesterol, 0.5% cholic acid and 5% lard. The melinamide-treated group receives the same diet but supplemented with 0.1% melinamide. Control rats are fed a standard chow (20 g/day). Following a 24-h fast the animals are killed. Blood is collected by aortic puncture and samples of small intestine are retained[3]. |
| References |
| Molecular Formula | C26H41NO |
|---|---|
| Molecular Weight | 383.61000 |
| Exact Mass | 383.31900 |
| PSA | 29.10000 |
| LogP | 8.06820 |
| Storage condition | 2-8℃ |