6491-83-4

6491-83-4 structure

Name: L-Leucyl-L-Leucine methyl ester hydrochloride
Chemical Name: ((S)-2-amino-4-methylpentanoyl)-L-leucine methyl ester hydrochloride
CAS Number: 6491-83-4
Molecular Formula: C₁₃H₂₇ClN₂O₃
Molecular Weight: 294.818
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-06-20 16:40:23
Modify Date: 2024-01-02 23:21:55
L-Leucyl-L-Leucine methyl ester (LLOMe) hydrochloride, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrochloride also can induce endolysosomal pathway stress[1][2][3].

Name	((S)-2-amino-4-methylpentanoyl)-L-leucine methyl ester hydrochloride
Synonyms	leucylleucinemethylesterhydrochloride HClH-L-Leu2-OMe L-Leucine, L-leucyl-, methyl ester, hydrochloride (1:1) (-) H-Leu-Leu-OMeHCl L-Leucyl-L-Leucine methyl ester (hydrochloride) leucylleucine methyl ester hydrochloride (Leu)2-OMe hydrochloride Methyl L-leucyl-L-leucinate hydrochloride (1:1) L-leucinyl-leucine methyl ester hydrochloride

Description	L-Leucyl-L-Leucine methyl ester (LLOMe) hydrochloride, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrochloride also can induce endolysosomal pathway stress[1][2][3].
Related Catalog	Research Areas >> Inflammation/Immunology
In Vitro	L-Leucyl-L-Leucine methyl ester (1 mM; 0.5-2 h) enhances LRRK2-mediated Rab10 and Rab12 phosphorylation in MEFs and A549 cells[3]. L-Leucyl-L-Leucine methyl ester (10-250 μM; 15 min) is converted to a CCI3COOH-insoluble product by CD4- lymphocytes[2].
References	[1]. Thiele DL, et, al. The immunosuppressive activity of L-leucyl-L-leucine methyl ester: selective ablation of cytotoxic lymphocytes and monocytes. J Immunol. 1986 Feb 1;136(3):1038-48. [2]. Thiele DL, et, al. Mechanism of L-leucyl-L-leucine methyl ester-mediated killing of cytotoxic lymphocytes: dependence on a lysosomal thiol protease, dipeptidyl peptidase I, that is enriched in these cells. Proc Natl Acad Sci U S A. 1990 Jan;87(1):83-7. [3]. Kalogeropulou AF, et, al. Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity. Biochem J. 2020 Nov 27;477(22):4397-4423.