1350920-22-7

1350920-22-7 structure

Name: T.cruzi-IN-1
Chemical Name: N-benzyl-N-methyl-1-(4-(trifluoromethyl)benzyl)piperidine-3-carboxamide
CAS Number: 1350920-22-7
Molecular Formula: C₂₂H₂₅F₃N₂O
Molecular Weight: 390.44200
Catalog: Research Areas Infection
Create Date: 2018-02-19 10:32:24
Modify Date: 2024-01-30 19:34:50
T.cruzi-IN-1 is a potent Trypanosoma cruzi inhibitor with an IC50 of 8 nM. T.cruzi-IN-1, a 4-trifluoromethyl substituted analog, has the potential for both the acute and chronic stages of Chagas disease[1].

Name	N-benzyl-N-methyl-1-(4-(trifluoromethyl)benzyl)piperidine-3-carboxamide

Description	T.cruzi-IN-1 is a potent Trypanosoma cruzi inhibitor with an IC50 of 8 nM. T.cruzi-IN-1, a 4-trifluoromethyl substituted analog, has the potential for both the acute and chronic stages of Chagas disease[1].
Related Catalog	Research Areas >> Infection
Target	IC50: 8 nM (Trypanosoma cruzi)[1]
In Vitro	T.cruzi-IN-1 inhibits Trypanosoma cruzi replication and has an IC50 of 61.6 μM for toxicity[1].
References	[1]. Germain AR, et al. Identification of small-molecule inhibitors of Trypansoma cruzi replication. Bioorg Med Chem Lett. 2011 Dec 1;21(23):7197-200.