6209-65-0

6209-65-0 structure

Name: Heliotrine N-oxide
Chemical Name: heliotrine N-oxide
CAS Number: 6209-65-0
Molecular Formula: C₁₆H₂₇NO₆
Molecular Weight: 329.38900
Catalog: Signaling Pathways Others Others
Create Date: 2018-04-08 21:31:51
Modify Date: 2025-08-21 13:24:45
Heliotrine N-oxide is the corresponding PA (pyrrolizidine alkaloid) N-oxide of Heliotrine (HY-126128). Heliotrine N-oxide leads to the formation of pyrrolic DNA adducts and potential initiation of PA-induced liver tumors in vivo[1].

Name	heliotrine N-oxide
Synonyms	(2S,3R)-2-hydroxy-2-isopropyl-3-methoxy-butyric acid-((7aR)-7c-hydroxy-4-oxy-(4ξ,7ar)-5,6,7,7a-tetrahydro-3H-pyrrolizin-1-ylmethyl ester) (2S,3R)-2-Hydroxy-2-isopropyl-3-methoxy-buttersaeure-((7aR)-7c-hydroxy-4-oxy-(4ξ,7ar)-5,6,7,7a-tetrahydro-3H-pyrrolizin-1-ylmethylester) [(7S,8S)-7-hydroxy-4-oxido-5,6,7,8-tetrahydro-3H-pyrrolizin-4-ium-1-yl]methyl2-hydroxy-2-(1-methoxyethyl)-3-methylbutanoate

Description	Heliotrine N-oxide is the corresponding PA (pyrrolizidine alkaloid) N-oxide of Heliotrine (HY-126128). Heliotrine N-oxide leads to the formation of pyrrolic DNA adducts and potential initiation of PA-induced liver tumors in vivo[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	DNA adduct is a segment of DNA bound to a cancer-causing chemical. This process could be the start of a cancerous cell, or carcinogenesis.
References	[1]. Xiaobo He, et al. Pyrrolizidine alkaloid-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides. J Food Drug Anal. 2017 Oct;25(4):984-991.