220384-25-8
220384-25-8 structure
- Name: ShK-Dap22
- Chemical Name: (Dap22)-Stichodactyla helianthus Neurotoxin (ShK)
- CAS Number: 220384-25-8
- Molecular Formula: C166H268N54O48S7
- Molecular Weight:
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
- Create Date: 2016-09-11 08:11:26
- Modify Date: 2025-09-15 14:12:35
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ShK-Dap22 is a potent Kv1.3-specific immunosuppressive Polypeptide. ShK-Dap22 is a selective Kv1.3 channel blocker with IC50s of 23 pM, 1.8 nM, 10.5 nM, 37 nM, and 39 nM for mKv1.3, mKv1.1, hKv1.6, mKv1.4, and rKv1.2 channels, respectively[1].
| Name | (Dap22)-Stichodactyla helianthus Neurotoxin (ShK) |
|---|
| Description | ShK-Dap22 is a potent Kv1.3-specific immunosuppressive Polypeptide. ShK-Dap22 is a selective Kv1.3 channel blocker with IC50s of 23 pM, 1.8 nM, 10.5 nM, 37 nM, and 39 nM for mKv1.3, mKv1.1, hKv1.6, mKv1.4, and rKv1.2 channels, respectively[1]. |
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| Related Catalog | |
| In Vitro | ShK-Dap22 suppresses T cell activation in vitro. ShK-Dap22, at subnanomolar concentrations, suppresses anti-CD3 induced human T-lymphocyte [3H]thymidine incorporation in vitro[1]. |
| References |
| Molecular Formula | C166H268N54O48S7 |
|---|