508-24-7

508-24-7 structure

Name: Tumulosic acid
Chemical Name: Tumulosic acid
CAS Number: 508-24-7
Molecular Formula: C₃₁H₅₀O₄
Molecular Weight: 486.72600
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-06-28 12:02:26
Modify Date: 2025-08-22 15:51:32
Tumulosic acid, a triterpenoid, inhibits KLK5 protease activity (IC50= 14.84 μM). Tumulosic acid suppresses the proteolytic processing of LL-37 in keratinocytes at ≤10 μM[1].

Name	Tumulosic acid
Synonyms	3β,16α-dihydroxy-eburica-8,24(28)-dien-21-oic acid 3β,16α-Dihydroxy-eburica-8,24(28)-dien-21-saeure 3β.16α-Dihydroxy-24-methylen-lanosten-(8)-saeure-(21) Tumulosaeure Tumulossaeure

Description	Tumulosic acid, a triterpenoid, inhibits KLK5 protease activity (IC50= 14.84 μM). Tumulosic acid suppresses the proteolytic processing of LL-37 in keratinocytes at ≤10 μM[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	Tumulosic acid displays dose-dependent anti-KLK5 activity (IC50=19.3 μM)[1]. Tumulosic acid decreases in LL-37 production in human keratinocytes[1]. Tumulosic acid shows IC50 values of 14.84 and 10.48 μM against KLK5 and trypsin proteases, while it exhibited a weak inhibitory effect on KLK7 and chymotrypsin C proteases (19.5% and 4.0%, respectively, at 100 μM)[1]. Western Blot Analysis[1] Cell Line: Normal human epidermal keratinocytes (NHEKs) Concentration: 1 μM and 10 μM Incubation Time: 23 h in the presence of 10 μM cycloheximide Result: Decreased LL-37 production in epidermal keratinocytes.
References	[1]. Matsubara Y, et al. Inhibition of Human Kallikrein 5 Protease by Triterpenoids from Natural Sources. Molecules. 2017;22(11):1829. Published 2017 Oct 27.