138614-30-9
138614-30-9 structure
- Name: Icatibant acetate
- Chemical Name: Icatibant acetate
- CAS Number: 138614-30-9
- Molecular Formula: C61H93N19O15S
- Molecular Weight: 1364.57000
- Catalog: Signaling Pathways GPCR/G Protein Bradykinin Receptor
- Create Date: 2018-02-16 08:00:00
- Modify Date: 2025-08-22 12:47:54
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Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively[1][2][3].
| Name | Icatibant acetate |
|---|---|
| Synonyms | Icatibant acetate |
| Description | Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vitro | Icatibant (10-30 μM) potentiates angiotensin III, but not angiotensin II (contraction mediated by angiotensin AT1 receptors), and Lys-des-Arg9-bradykinin, but not des-Arg9-bradykinin (effects mediated by the bradykinin B1 receptors)[3]. |
| In Vivo | Icatibant (10-30 μM) potentiates angiotensin III, but not angiotensin II (contraction mediated by angiotensin AT1 receptors), and Lys-des-Arg9-bradykinin, but not des-Arg9-bradykinin (effects mediated by the bradykinin B1 receptors)[3]. Animal Model: Female mice of the CBA/J (H-2k) strain[2]. Dosage: 0.06, 0.3, or 1.5 mg/kg. Administration: Subcutaneous administration twice daily. Result: The length of the large intestine was 93.6±6.8 mm with the 1.5 mg/kg dosage and 94.0±4.1 mm with the 0.3 mg/kg dosage , showing a significant preventive effect on shortening. |
| References |
| Density | 1.6g/cm3 |
|---|---|
| Molecular Formula | C61H93N19O15S |
| Molecular Weight | 1364.57000 |
| Exact Mass | 1363.68000 |
| PSA | 581.76000 |
| LogP | 1.67610 |
| Storage condition | -20℃ |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |