Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5-(2-FLUOROPHENYL)-1,3-DIHYDRO-3-(1H-INDOL-3-YLMETHYL)-1-METHYL-2H-1,4-BENZODIAZEPIN-2-ONE
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103342-82-1

103342-82-1 structure

Name: L-364373
Chemical Name: (3R)-5-(2-fluorophenyl)-3-(1H-indol-3-ylmethyl)-1-methyl-3H-1,4-benzodiazepin-2-one
CAS Number: 103342-82-1
Molecular Formula: C₂₅H₂₀FN₃O
Molecular Weight: 397.44400
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2017-03-10 09:11:05
Modify Date: 2025-08-25 19:48:54
L-364,373 (R-L3) is a voltage-gated Kv7.1 (KCNQ1)/mink channels activator. L-364,373 activates Iks (slow delayed rectifier potassium current) and shortens action potential duration in guinea pig cardiac myocytes, and suppresses early afterdepolarizations in rabbit ventricular myocytes[1].

Name	(3R)-5-(2-fluorophenyl)-3-(1H-indol-3-ylmethyl)-1-methyl-3H-1,4-benzodiazepin-2-one
Synonyms	L-364,373 CCK antagonist synthetic 11 R-L364,373 R-L3

Description	L-364,373 (R-L3) is a voltage-gated Kv7.1 (KCNQ1)/mink channels activator. L-364,373 activates Iks (slow delayed rectifier potassium current) and shortens action potential duration in guinea pig cardiac myocytes, and suppresses early afterdepolarizations in rabbit ventricular myocytes[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
References	[1]. Jow F, et al. Rb+ efflux through functional activation of cardiac KCNQ1/minK channels by the benzodiazepine R-L3 (L-364,373). Assay Drug Dev Technol. 2006 Aug;4(4):443-50.