121695-87-2

121695-87-2 structure

Name: Sarafotoxin C trifluoroacetate salt
Chemical Name: Sarafotoxin S6c
CAS Number: 121695-87-2
Molecular Formula: C₁₀₃H₁₄₇N₂₇O₃₇S₅
Molecular Weight: 2515.75000
Catalog: Signaling Pathways GPCR/G Protein Endothelin Receptor
Create Date: 2018-09-27 08:16:46
Modify Date: 2024-01-02 14:19:33
Sarafotoxin S6c (SRTX-c) is a potent endothelin-B receptor agonist. Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels[1].

Name	Sarafotoxin S6c
Synonyms	MFCD00133969 SRTX-c Sarafotoxin S 6c Sarafotoxin 6c

Description	Sarafotoxin S6c (SRTX-c) is a potent endothelin-B receptor agonist. Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor
Target	Endothelin-B receptor[1]
In Vivo	Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels[1]. Animal Model: Male Wister rats, exposed to 10% O2 [chronic hypoxic (CH) rats] or room air (control rats) for 2 weeks[1] Dosage: 1 pM-1 mM Administration: Result: Chronic hypoxia had effect on the sensitivity of the main pulmonary arteries to SCS6c, and small vasoconstrictor responses to were evident. Caused vasoconstriction with a maximum response 30% of that to ET-1 in both endothelium-intact and endothelium-denuded vessels.

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